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Inventi Impact: Animal Models & Cell Assays

Articles

  • Inventi:pac/31362/20
    Genome-Wide Association Study and Subsequent Exclusion of ATCAY as a Candidate Gene Involved\nin Equine Neuroaxonal Dystrophy Using Two Animal Models
    Research 2020 : April - June
    Erin N Hales, Christina Esparza, Sichong Peng, Anna R Dahlgren, Janel M Peterson, Andrew D Miller, Carrie J Finno

    Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (eNAD/EDM)\nis an inherited neurodegenerative disorder of unknown etiology. Clinical signs of neurological\ndeficits develop within the first year of life in vitamin E (vitE) deficient horses. A genome-wide\nassociation study (GWAS) was carried out using 670,000 SNP markers in 27 case and 42 control\nQuarter Horses. Two markers, encompassing a 2.5 Mb region on ECA7, were associated with the\nphenotype (p = 2.05 * 10-7 and 4.72 * 10-6). ................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Hales, Erin N., et al. \"Genome-Wide Association Study and Subsequent Exclusion of\nATCAY as a Candidate Gene Involved in Equine Neuroaxonal Dystrophy Using Two Animal Models.\" Genes 11.1 (2020):\n82.\nhttps://doi:10.3390/genes11010082\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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